I would like to find out if taking part in the people’s trial makes a difference to the public enthusiasm for clinical trials in comparison to bit taking part? 1

I would like to find out if swelling of the ankles in the elderly (especially in warm weather) is more effectively treated with compression stockings, diuretics in comparison to combination of the two. 2, 3, 4, 5

I would like to find out if an air conditioner makes a difference to the risk for having a cold? 6 As doctors get older, their professional skills get worse? 6 Reducing pills in old people (>75 years old) is better than maintaining the pill-load (>5 drugs)? 6

I would like to find out if  exercise (walking, jogging, cycling) outside in an urban atmosphere makes a difference to health benefits and results of exposure to pollution trials in comparison to indoors exercise regimes? 2, 5, 8

I would like to find out if being blonde makes a difference to levels of fun in comparison to having another hair colour? 2

I would like to find out if obstetric interventions on mothers and babies makes a difference to unnecessary harm in comparison to more holistic care such as midwifery continuity of care? 2, 4, 5

I would like to find out if the choice of outcome measures in clinical trials (objective outcomes vs self-report) makes a difference to how relevant the patients think the outcome measure is in comparison to the researchers in the field, objective measures of functioning compared to subjective/self-report outcome measures? 7

I would like to find out if singing in a choir makes a difference to happiness in comparison to not singing in a choir? 2

I would like to find out if a light dinner makes a difference to getting up in early morning in comparison to a heavy dinner? 1

I would like to find out if drinking isotonic drinks makes a difference to running speed in comparison to drinking water? 2

I would like to find out if drinking hot tea makes a difference to recovery from a common cold in comparison to drinking the same amount of other fluids? 5, 7

I would like to find out if having had glandular fever at a young age makes a difference to physical and mental energy levels and fitness as an adult in comparison to not having had glandular fever at a young age? 1, 5

I would like to find out if walking under a ladder makes a difference to luck in comparison to bypassing the ladder? 2

I would like to find out if  going out with your hair wet makes a difference to catching a cold in comparison to drying your hair before going out 5, 7

I would like to find out if drinking alcohol makes a difference to quality of sleep in comparison to not drinking alcohol? 1

If you normally wear glasses I would like to find out if this makes a difference to hearing people if you don’t have them on in comparison to if you do have them on? 2

What age is it best to go back to work after your baby? Stay longer at home? 6 months? 2

I would like to find out if going high on a swing makes a difference to a 1 year old’s laughter in comparison to going down a slide head first? 2

I would like to find out if eating truly organic foods makes a difference to your blood sugar in comparison to eating non-organic foods? 2, 5, 8

I would like to find out if drinking 4 cups of real coffee per day makes a difference to my heart rate in comparison to decaffeinated coffee? 2

I would like to find out if teaching mindfulness to primary school children makes a difference to children’s health and well-being in comparison to standard school pastoral care without mindfulness training? 2

I would like to find out if having a desk job makes a difference to weight gain in comparison to a more active job? 5, 7, 8

I would like to find out if changing your social class makes a difference to your health and wellbeing? 1,2

I would like to find out if eating Breakfast makes a difference to weight loss in comparison to not having any breakfast at all? 5, 7, 8

I would like to find out if not eating carbs after 5pm while on a balanced weight loss diet makes a difference to losing weight in comparison to eating carbs after 5pm? 5, 7, 8

I would like to find out if eating chees makes a difference to not eating cheese? 6

I would like to find out if drinking coffee makes a difference to making your skin look younger in comparison to not drinking coffee? 5, 7

I would like to find out if yoga and meditation make a difference to blood pressure in comparison to medication only? 3, 8

I would like to find out if going to bed with wet hair makes a difference to getting a head cold/cough/sore throat in comparison to going to bed with dry hair? 5, 7

I would like to find out if going to bed with wet hair makes a difference to getting a cold/make you sick in comparison to going to bed with fully dry hair? 5, 7

I would like to find out if the bad weather makes a difference to your mood in comparison to good weather? 1

I would like to find out if melatonin tablets make a difference to flying long distance east T? 2, 4, 5, 7, 8

I would like to find out if the internet should be banned for children? 6Can you really make money from YouTube? 6 Should children work on environmental issues after school or during the Gap year? 6

I would like to find out if cycling for long periods of time makes a difference to fertility in men in comparison to low levels or no cycling? 2, 5, 8

I would like to find out if a guaranteed income for everyone over 18 makes a difference to self-reported health, wellbeing and happiness in comparison to no guaranteed income? 1, 2

I would like to find out if eating carrots makes a difference to seeing in the dark in comparison to not eating carrots? 7, 8

I would like to find out if  taking Mg2+ supplements (not MgO) makes a difference to getting calf (or other) cramps during swimming (or other sports) in comparison to not taking Mg2+ supplements? 2, 4

Grey hair is linked to reduced hormone levels. I would like to find out if introducing hormones makes a difference to maintaining hair colour through old age in comparison to no intervention? 2, 4, 5, 8

I would like to find out if dunking biscuits in tea makes a difference to how many cups of tea consumed in a day in comparison to non-biscuit tea dunkers? 2, 7

I would like to find out if intermittent fasting makes a difference to stable blood glucose levels in comparison to three meals a day for diabetics? 3, 5, 8

I would like to find out if good posture makes a difference to having aches and pains in comparison to bad posture? 1, 7

I would like to find out if alternative therapies such as cider vinegar, turmeric, or even sea buckthorn berries make a difference to psoriatic arthritis in comparison to standard therapies? 3, 4, 5

I would like to find out if the use of pop-up computer reminders to monitor body posture during work hours make a difference to head and neck pain in comparison to not using pop-up computer reminders to monitor body posture during work hours? 2, 5

I would like to find out if consuming cannabis makes a difference to hospital admissions in comparison to not consuming cannabis? 3,

I would like to find out if flexible and at-home working makes a difference to mental load in comparison to fixed office hours? 2

I would like to find out if getting anger makes a difference to Hepatic injury in comparison to not getting anger? 3, 5, 7, 8

I would like to find out if working in an open-plan office makes a difference to work productivity in comparison to working in another type of office plan (e.g. separate rooms)1,2

I would like to find out if topical magnesium makes a difference to symptoms of magnesium deficiency including restless legs, Reynaud’s and chocolate cravings in comparison to oral magnesium or placebo? 3, 4, 5, 8

I would like to find out if cycling to work makes a difference to well-being and weight in comparison to driving or taking public transport? 2, 5

I would like to find out if plant-based diets makes a difference to preventing and reversing the leading cause of preventable deaths (Cardiovascular disease, prostate, colon and breast cancers, Type 2 Diabetes, Osteoporosis etc) in comparison to a western meat based diet? 5, 7, 8

I would like to find out if  flat 7-up makes a difference to sickness in comparison to fizzy 7-up? 5, 7

I would like to find out if eating large amounts of vitamin C makes a difference to the start of menstrual bleeding in women (i.e., shorter period) in comparison to normal amounts of vitamin C? 2, 5

I would like to find out if yoga makes a difference to well-being in comparison to meditation? 2

I would like to find out if drinking water and nothing else makes a difference to kidney disease in stage 3 CKD in comparison to drinking a variety of beverages? 3, 5, 8

I would like to find out if  taking only an increased dosage of probiotics makes a difference to one’s state of well-being during enterocolitis in comparison to antibiotics only treatment (where the case)? 3, 4, 5, 8

I would like to find out if keeping your ears covered makes a difference to a viral ear infection in comparison to not covering your ears? 3, 5

I would like to find out if an apple a day make a difference to keeping the doctor away in comparison to not eating an apple a day? 7

I would like to find out if living on the third floor of an apartment building makes a difference to contracting Dengue fever in comparison to living in the first floor? 1, 3, 5, 8

I would like to find out if early rising makes a difference to happiness and mental health in comparison to being a night owl? 1

I would like to find out if eating Quinoa makes a difference to raising iron levels in the body in comparison to beef? 2, 8

I would like to find out if working a four day week makes a difference to mental health, wellbeing and outlook on life in comparison to working a five day week? 1, 2

I would like to find out if having a cold shower on a hot day makes a difference to body temperature in comparison to having a hot shower? 8

I would like to find out if looking at a video on climate change makes a difference to traveling by plane, eating meat, using public transportation in comparison to looking at a video on a different topic (eg bear cubs)? 7

I would like to find out if exercising at a high temperature (e.g. 37 C for hot yoga) makes a difference to fitness, as measured by cardiovascular capacity in comparison to exercising at room temperature? 5, 8

I would like to find out if refraining from eating after 7 o’clock in the evening makes a difference to  weight loss in comparison to eating after 7 o’clock ( as part of a balanced diet)? 5, 7, 8

I would like to find out if eating meat makes a difference to migraine in comparison to not eating meat? 3, 7

I would like to find out if exercising on an empty stomach make a difference to weight loss in comparison to exercising on a full stomach? 5, 7, 8

I would like to find out if eating dark chocolate makes a difference to weight loss in comparison to eating regular chocolate?  5, 7, 8

I would like to find out if sleeping with your hair wet makes a difference to becoming sick (colds and etc.) in comparison to sleeping with your hair dry? 5, 7

I would like to find out if eating an apple a day make a difference to attending the doctors in comparison to not eating apples? 7

I would like to find out if being a smoker makes a difference to being a vegetarian in comparison to not being a smoker? 1

I would like to find out if ‘teething’ in babies makes a difference to nappy rash in comparison to not ‘teething ‘babies?  2, 5

I would like to find out if a meat free diet makes a difference to a healthy body composition in comparison to eating meat daily? 5, 7

I would like to find out if being an adult over six feet tall makes a difference to performing more effective CPR compressions in comparison to Adults under six feet tall? 1

I would like to find out if exercising regularly makes a difference to developing dementia in comparison to not exercising?  5, 7, 8

I would like to find out if eating a meat only based diet makes a difference to your general and long-term health in comparison to eating as a vegan? 5, 7

I would like to find out if cracking your fingers and knuckles makes a difference to developing arthritis in comparison to not cracking them? 5, 7, 8

I would like to find out if pulling one white hair makes a difference to the number of white hairs in comparison to not pulling white hairs? 2

I would like to find out if using Coconut oil makes a difference to teeth whiteness in comparison to other natural treatments? 2

I would like to find out if new government policies make a difference to the health and wealth of the nation in comparison to current government policies? 1, 7

I would like to find out if a course of antibiotics makes a difference to the gut biome and if it is how long it takes to recover? 3, 4, 5, 7, 8

I would like to find out if walking with a dog makes a difference to mood in comparison to walking alone? 2

I would like to find out if  listening to/watching true crime makes a difference to the likelihood of being a victim of a crime in comparison to people who do not listen to/watch true crime?7

I would like to find out if  taking the (this section left blank by participant) makes a difference to side effects on your body as nausea and decreased appetite in comparison to taking a traditional medicaments for treating H pylori? 3, 4, 5, 8

Are people who can curl their younger and flip their youngest to the side smarter than those who cannot? I would like to find out if this make a difference to intelligence or is it passed on genetically? Or can it be learnt? 6

I would like to find out if hearing others success stories makes a difference to one’s mental health in comparison to hearing ones advice? 5, 7

I would like to find out if undergoing heart surgery as a child makes a difference to mental health?  In children who have undergone childhood cardiac surgery I would like to find out if a CBT type intervention/awareness/regular monitoring during childhood makes a difference to mental health issues in later life in comparison to no intervention at all? 3, 4, 5

I would like to find out if implementing methods of reducing eye strain at work e.g. breaks, blinking, and brightness of screen relative to room makes a difference to fatigue, red eye, and headache reduction in comparison to no intervention? 3, 5

I would like to find out if dietary intake of milk makes a difference to levels of soluble calcium in comparison to milk derivatives e.g. yogurt, cheese etc.? 8

I would like to find out if listening to music while running makes a difference to weight loss in comparison to not listening to music? 5, 7, 8

I would like to find out if free standing desks make a difference to short- and long-term health outcomes in comparison to conventional seated desks? 5, 7

I would like to find out if mobile cell/ device usage makes a difference to abnormal cell growth in comparison to not using electronic cell/ Wi-Fi usage? 3, 5, 8

I would like to find out if believing in God make a difference to mental peace and happiness in comparison to not believing in God? 1

I would like to find out if Dock leaves make a difference to nettle stings in comparison to Sudo cream? 2

I would like to find out if applying menthol-based toothpaste on mosquito bites makes a difference to itchiness, redness and swelling in comparison to not applying menthol-based toothpaste? 5

I would like to find out if  eating a very low-carbohydrate diet/ a ketogenic diet makes a difference to health markers in healthy adults (blood glucose control, blood fats, micronutrient status, kidney function, body composition) in comparison to a healthy diet as recommended by current dietary guidelines? 5, 7, 8

I would like to find out if using public transport makes a difference to quality of Life in comparison to travelling by private car? 2

What is the cure for migraines? How can it be prevented? What are the sad comparisons to the quality of life to those that suffer and those that don’t? 3, 5, 6

I would like to find out if eating carrots makes a difference to night vision in comparison to not eating carrots? 7, 8